White-matter disease of prematurity, periventricular leukomalacia, and ischemic lesions
نویسندگان
چکیده
منابع مشابه
Focal necrosis of the white matter (periventricular leukomalacia): sonographic, pathologic, and electroencephalographic features.
Eleven preterm infants (gestational ages 27-35 weeks) with echogenic paraventricular white matter identified shortly after birth were studied with serial echoencephalograms to fully delineate the sonographic findings characterizing the pathologic stages of white-matter necrosis. Echoencephalograms were compared with autopsy findings and CT scans. Cerebral function was assessed by electroencepha...
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The prospect of declining cognitive functions is a major fear for many elderly persons. Cerebral white matter lesions, as commonly found with magnetic resonance imaging, have been associated with cognitive dysfunction in cross-sectional studies. Only a few longitudinal studies using small cohorts confirmed these findings. We examined the relation between severity of white matter lesions and cog...
متن کاملDiffusion tensor imaging in children with periventricular leukomalacia: variability of injuries to white matter tracts.
BACKGROUND AND PURPOSE Conventional MR imaging shows evidence of brain injury and/or maldevelopment in 70%-90% of children with cerebral palsy (CP), though its capability to identify specific white matter tract injury is limited. The great variability of white matter lesions in CP already demonstrated by postmortem studies is thought to be one of the reasons why response to treatment is so vari...
متن کاملNMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.
Hypoxia-ischemia (H/I) in the premature infant leads to white matter injury termed periventricular leukomalacia (PVL), the leading cause of subsequent neurological deficits. Glutamatergic excitotoxicity in white matter oligodendrocytes (OLs) mediated by cell surface glutamate receptors (GluRs) of the AMPA subtype has been demonstrated as one factor in this injury. Recently, it has been shown th...
متن کاملWhite Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors
Periventricular leukomalacia (PVL) is the most frequent cause of cerebral palsy and other intellectual disabilities, and currently there is no treatment. In PVL, glutamate excitotoxicity (GME) leads to abnormal oligodendrocytes (OLs), myelin deficiency, and ventriculomegaly. We have previously identified that the combination of transferrin and insulin growth factors (TSC1) promotes endogenous O...
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ژورنال
عنوان ژورنال: Developmental Medicine & Child Neurology
سال: 2008
ISSN: 0012-1622,1469-8749
DOI: 10.1111/j.1469-8749.1998.tb15417.x